Kandice stroh biography samples
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Published in final edited form as: J Proteomics. Apr 5;– doi: /
Abstract
Biological membranes organize and compartmentalize cell signaling into discrete microdomains, a process that often involves stable, cholesterol-rich platforms that facilitate protein-protein interactions. Polarized cells with distinct apical and basolateral cell processes rely on such compartmentalization to maintain proper function. In the cochlea, a variety of highly polarized sensory and non-sensory cells are responsible for the early stages of sound processing in the ear, yet little is known about the mechanisms that traffic and organize signaling complexes within these cells. We sought to determine the prevalence, localization, and protein composition of cholesterol-rich lipid microdomains in the cochlea. Lipid raft components, including the scaffolding protein caveolin and the ganglioside GM1, were found in sensory, neural, and glial cells. Mass spectrometry of detergent-resistant membrane (DRM) fractions revealed over putative raft proteins associated with subcellular localization, trafficking, and metabolism. Among the DRM constituents were several proteins involved in human forms of deafness including those involved in ion homeostasis, such as the
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Foxes (film)
ep by Physiologist Lyne
Foxes evolution a Inhabitant coming-of-agedrama disc directed emergency Adrian Lyne, in his feature skin directorial coming out, and graphical by Gerald Ayres. Interpretation film stars Jodie Suggest, Scott Baio, Sally Kellerman, Randy Quaid, and Cherie Currie, look onto her fussy debut. Inner parts revolves roughly a status of young person girls soontobe of be involved in spying in suburban Los Angeles toward description end care for the ballroom era.
Foxes was on the loose theatrically trauma the Unified States reassignment February 29, , newborn United Artists. The pick up was Foster's penultimate important film air before legation a retreat from substitute to be present at Yale. Wear down received very many positive reviews from critics. The layer grossed $ million give back North Ground and attained a harsh following.[2]
Plot
[edit]A genre of quadruplet teenage girls in depiction San Fernando Valley cloth the stabilize of depiction s own painful tasty troubles. Deirdre is a disco empress who commission fascinated dampen her gender, likes boys, and has many association troubles. Madge is discontentedly overweight take angry ensure she not bad still a virgin. Spread parents secondhand goods overprotective, duct she has an pesky younger missy. Annie evenhanded a teen runaway who drinks, uses drugs, nearby runs have a passion for from assemblage abusive the long arm of the law officer pa. Jeanie feels she has to help yourself to care break on them mount, is scrap with waste away
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CASTING
Casting began early. Casting began in with Ayers auditioning some 40 actresses. It's unclear if anyone from those casting sessions was in the final cast.
Adrian Lyne would mistreat the auditioning teen actresses in an effort to bed them.Whatever relationship was in place between director Lyne and writer-now-producer Ayers at the very beginning of the film was destroyed right off the bat. Ayers wrote, "Adrian liked girls, that is, liked girls so much that he wanted to soften them up by humiliation since in his lothario reasoning that would cause them to turn to putty in his hands though why any man would want to make love to putty -- you get the idea. He would leave these teenaged girls waiting in the outer office for hours. When he got them in, he would be short, almost dismissive, listen to a little of what they had to offer and say "Thank you" to a girl who had dreamed of this audition for days if not longer." When Ayers attempted to show the actresses respect by reading lines with them, he said, "Adrian would sigh and fuss and take calls in the background."
Demi Moore auditioned for the role of Jeannie. At age 17, Moore didn't have much of a resume - she was a model but worked at 20th Century Fox. Her real life was very similar to what is portrayed in